Endocrine Abstracts

After diabetes, thyroid disorder is the second most common endocrine disorder in women of reproductive age. Thyroid disorders in pregnancy have been proven to have adverse maternal and foetal outcome if not treated adequately and timely.Aim: The aim of this audit was to assess management and therapeutic interventions and outcomes of pregnancies complicated by thyroid disorders.Method: A retrospective case notes analysis of 35 pregn...

After diabetes, thyroid disorder is the second most common endocrine disorder in women of reproductive age. Thyroid disorders in pregnancy have been proven to have adverse maternal and foetal outcome if not treated adequately and timely.Aim: The aim of this audit was to assess management and therapeutic interventions and outcomes of pregnancies complicated by thyroid disorders.Method: A retrospective case notes analysis of 35 pregn...

This is the case 32y old Asian lady, who first presented to her GP in October 2013 with weight loss, palpitations and fatigue and found to have overactive thyroid. She has not experienced any neck pain or systemic illness. She has some neck tenderness but not goitre or any extra-thyroidal manifestation of Graves’ disease, hence the thyroid nucleotide scan was requested. His scan was consistent with thyroiditis. By January 2014 her thyroid function test normalized with TSH...

44 years old lady was referred to Endocrinology Clinic with history of secondary amenorrhea and hyperprolactinaemia (7800), that responded to Cabergolin treatment, which was discontinued after 2 months due to side effects (headaches). There was no galactorrhea or visual field defects. MRI Pituitary initially reported as Empty Sella. Her prolactin levels rose further along with headach after she discontinued Cabergoline (and refused alternatives). She eventually agreed for nigh...

Carbimazole is a commonly used antithyroid drug with a rare but potentially life-threatening side effect of agranulocytosis. We present a case of a 47-year-old lady who was diagnosed with hyperthyroidism four years previously and treated with carbimazole despite persistent neutropenia.At diagnosis the patient had clinical features of hyperthyroidism and thyroid function test (TFT) showed free T4 40.8 pmol/l (10.6–21.0), free T3...

Introduction: Weight gain following treatment of hyperthyroidism is well recognised. This may lead to compliance problems both in patients with/without eating disorders and subsequent failure of therapy. We describe two cases where this was successfully managed with supervised in-patient therapy.Case 1: A 30-year-old overweight lady was diagnosed with Grave’s disease following childbirth. Thyroid function test (TFT) at initiation of treatment showed...

Ovarian hyperthecosis is a rare cause of androgenic alopecia in postmenopausal women. The physiological levels of androgens, secreted by ovarian stromal cells, are greatly increased with hyperplastic or neoplastic transformation leading to possible clinical consequences.We report a case of 56-year-old woman with type 2 diabetes presenting with hirsuitism and a history of male pattern hair loss over a two-year period. Biochemistry showed elevated levels o...

Ovarian hyperthecosis is a rare cause of androgenic alopecia in postmenopausal women. The physiological levels of androgens, secreted by ovarian stromal cells, are greatly increased with hyperplastic or neoplastic transformation leading to possible clinical consequences.We report a case of a 56-year-old woman with type 2 diabetes presenting with hirsuitism and a history of male pattern hair loss over a two year period. Biochemistry showed elevated levels...

Introduction: Hypercalcemia with pheochromocytoma usually occurs as part of MEN syndrome associated with parathyroid adenomas or hyperplasia. Here, we present a case of malignant pheochromocytoma with hypercalcemia caused by the secretion of PTHrP secretion tumour itself. Hypercalcemia was corrected on by the removal of the malignant pheochromocytoma.Case: A 75-year-old gentleman with PMHx of hypertension presented with a history of fall and head injury ...

Introduction: Diabetes-related ketoacidosis (DKA) is an acute endocrine emergency requiring immediate diagnosis and management. Common misconception is that DKA is associated with type 1 diabetes only. We explored the proportion of people with type 2 diabetes, and compared the management, complications and outcome of DKA between people with type 1 and type 2 diabetes.Methods: We conducted a retrospective study on people admitted with DKA across six hospi...